Mechanism of action of ULEINE

ULEINE promotes synthesis of NO in macrophages Ref.: Souza WM et al, 2007, Rev. Bras. Farmacogn. vol.17 no. 2 João Pessoa Apr./Ju ne 2007, 191-196


Nitric oxide is the primary molecule synthesized by macrophages and other cells pertaining to the immune system to inactivate external and internally produced destabilizing agents as viruses, bacteria and cancers. Some pathogens, as the HIV and Tuberculosis, multiply in macrophages and other immune cells and thus directly impact their capacity to destroy the pathogens.
Uleine promotes the synthesis of the powerfully reactive chemical nitric oxide (NO) and reduces the susceptibility of the organism in a preventive way to infection by invading pathogens as well as of internally produced tumor cells that escape the normal immunological homeostasis of the organism. Uleine was found to be the active principle present in the bark of the plant Aspidosperma subinanum.